Study Reveals Key to Liposome Accumulation in Tumors for Better Cancer Drug Delivery
A recent study published in ACS Nano has shed light on the accumulation of liposomes in tumours using different fluorescent labels. The research, titled 'Liposomal Extravasation and Accumulation in Tumors as Studied by Fluorescence Microscopy and Imaging Depend on the Fluorescent Label', was conducted on breast cancer and brain cancer mouse models.
Two types of fluorescent lipids, indocarbocyanine lipids (ICLs) and fluorescent phospholipids (FPLs), were employed in the study. The results revealed that ICLs demonstrated remarkable accumulation and infiltration in tumours, whereas FPLs did not show significant extravasation and eventually disappeared over time. The team behind the study plans to expand their research to include additional fluorescent lipids for potential therapeutic use.
The findings of this study could pave the way for improved cancer drug-delivery systems. By understanding the behaviour of different fluorescent lipids in tumours, researchers can develop more effective liposomal formulations for targeted cancer therapy.
