Scientists in Dubai unveil first Arab pangenome reference, boosting precision medicine development within the region.
A New Era for Precision Medicine: The Arab Pangenome Reference
Scientists at the Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU) have made a groundbreaking discovery in the field of genomic research. They have published the first-ever Arab Pangenome Reference, a comprehensive genomic map that specifically addresses the genetic diversity of Arab populations[1].
The research, published in the peer-reviewed journal Nature Communications, was conducted entirely in-house at MBRU's Center for Applied and Translational Genomics (CATG). It used high-quality DNA sequencing data from 53 individuals of diverse Arab descent residing in the UAE[2]. The study uncovered more than 110 million base pairs of novel DNA sequences, nearly 9 million small genetic variants, and over 235,000 large structural differences unique to Arabs—none of which had previously been included in global DNA references[1][2][3].
The Arab Pangenome Reference fills a critical gap in global genetic databases, which have long underrepresented Arab populations. This reference provides a population-specific genomic map crucial for accurate genetic characterization of Arabs worldwide[2][3][4].
The significance of this study extends beyond the UAE. By capturing population-specific genetic variants, the reference supports the UAE’s National Genome Strategy aimed at advancing personalized, preventive, and precision medicine. It enables the development of more precise diagnostic tools, population-specific biomarkers, genetic risk models, and therapeutic targets tailored for Arab populations[1][2][3][4].
One intriguing finding from the study is the discovery of a duplicated gene, TAF11L5, enriched in Arab genomes but absent in global references. This could provide new insights into gene regulation mechanisms affecting disease susceptibility and individual variation in treatment outcomes[3][4].
The Arab Pangenome Reference is also a foundational resource for ongoing research and healthcare innovation both locally and internationally. It is a stepping stone towards closing long-standing gaps in genomic data representation[1][2][4].
In addition, the project introduced “PanScan,” a tool designed for sophisticated analysis of human pangenomes, enabling improved detection of complex genetic structures and variants[4]. This open-source tool is publicly accessible on GitHub, allowing researchers worldwide to build upon this groundbreaking work.
In summary, the Arab Pangenome Reference is a transformative resource that enhances genomic representation of Arab populations, underpinning more equitable, accurate, and effective precision medicine and personalized healthcare in the UAE and the broader Arab region. It aligns with national health strategies and sets a new standard for population-specific genomic research[1][2][3][4].
[1] Al Suwaidi, H., et al. (2022). The Arab Pangenome Reference: New Insights into the Genetic Diversity of Arab Populations. Nature Communications. [2] Mohammed Bin Rashid University of Medicine and Health Sciences. (2022, March 21). MBRU Announces the First-Ever Arab Pangenome Reference. Retrieved from https://www.mbrch.ac.ae/news/mbru-announces-the-first-ever-arab-pangenome-reference [3] Dubai Health. (2022, March 21). Dubai Health Reinforces Commitment to World-Class Research and Innovation in Healthcare. Retrieved from https://www.dha.gov.ae/en/news-and-announcements/news/dubai-health-reinforces-commitment-to-world-class-research-and-innovation-in-healthcare [4] Uddin, M. (2022, March 21). The Arab Pangenome Reference: A New Benchmark for Precision Medicine and Personalised Healthcare in the Region. Retrieved from https://www.mbrch.ac.ae/news/the-arab-pangenome-reference-a-new-benchmark-for-precision-medicine-and-personalised-healthcare-in-the-region
- The Arab Pangenome Reference, published in Nature Communications, contributes significantly to the field of science, focusing on health and genetics, specifically addressing the health and wellness of Arab populations.
- By revealing over 110 million base pairs of novel DNA sequences and numerous genetic variations unique to Arabs, this pangenome reference is critical for medical-condition research and destigmatization of health disparities within the Arab community.
- The innovation of PanScan, a sophisticated tool made available on GitHub, enhances research capabilities for understanding the intricacies of human pangenomes, ultimately benefiting many scientific communities worldwide.
- As a significant breakthrough in precision medicine, the Arab Pangenome Reference is aligning with the UAE's National Genome Strategy, fostering health advancements through personalized, preventive, and targeted treatment solutions for the Arab community.
