Research indicates potential for ginger in suppressing inflammation in autoimmune conditions
In a recent study published in JCI Insight, researchers observed an increase in cAMP within neutrophils when healthy participants took a ginger supplement daily for a week. This finding could have significant implications for those suffering from autoimmune diseases such as lupus, rheumatoid arthritis, and antiphospholipid syndrome.
Ginger has demonstrated anti-inflammatory effects, which may benefit autoimmune diseases by reducing excessive neutrophil activity and neutrophil extracellular trap (NET) formation, key contributors to inflammation in these conditions. The study reported that a daily 20mg ginger supplement for seven days increased cAMP levels in neutrophils, thereby inhibiting NETosis and potentially easing autoimmune-related inflammation.
Beyond this mechanism, ginger is known to inhibit inflammatory chemicals like prostaglandins and leukotrienes, involved in inflammatory responses and pain signaling in joint and muscle conditions. Additionally, its antimicrobial properties and immune-modulating effects may support overall immune health.
Regarding effective dosage, the specific study examining immune cell effects used a 20mg daily ginger supplement for a week to reduce NETosis. Other studies, focusing on pain and inflammation, generally used higher doses such as 2 grams daily of ginger powder or extract. The exact effective dose for systemic autoimmune inflammation is not yet firmly established, but 20mg daily shows promise for immune modulation, while up to 2 grams daily has been studied for broader inflammatory symptoms.
The study offers a good starting point for clinicians and patients who may already be interested in trying ginger supplementation for autoimmune conditions. If further research confirms its effectiveness, the use of ginger could revolutionize how autoimmune diseases are managed and treated.
Dr. Kristen Demoruelle, a senior co-author of the study, confirmed the findings are applicable to people and not just a finding seen in a test tube. Further research is needed to understand how this dosage affects individuals with autoimmune conditions. Kelsey Costa, a registered dietitian and nutrition consultant, noted that the study suggests ginger supplements could revolutionize the management of autoimmune diseases.
The study focused on the effect of ginger on neutrophils, a type of white blood cell. The researchers aim to conduct clinical trials to investigate ginger's effects on patients with autoimmune and inflammatory conditions. The research offers exciting revelations about the potential of ginger extract as a natural, complementary remedy for autoimmune diseases.
References:
[1] Demoruelle, K., et al. (2022). Ginger inhibits neutrophil extracellular trap formation in human neutrophils. JCI Insight.
[3] Costa, K. (2022). The potential role of ginger in autoimmune disease management. Healthline.
[5] Lee, J., et al. (2019). Efficacy of ginger in osteoarthritis: an updated systematic review and meta-analysis of randomized controlled trials. Journal of Medicinal Food.
