Potential adverse effects of Tavalisse, a detailed guide on recognizing them and ways to mitigate
In the treatment of chronic immune thrombocytopenia (ITP), three medications—Tavalisse (fostamatinib), Doptelet (avatrombopag), and Promacta (eltrombopag)—offer potential solutions, each with distinct side effect profiles.
Tavalisse (fostamatinib) is known for common side effects such as diarrhea, hypertension, nausea, headache, dizziness, and elevated liver enzymes. It also increases the risk of infections due to its immune-modulating effects. Serious adverse events can include hypertension and hepatotoxicity.
Doptelet (avatrombopag), generally well-tolerated, often causes side effects like headache, fatigue, nausea, and abdominal pain. There is a potential risk for thromboembolic events (blood clots) because it stimulates platelet production.
Promacta (eltrombopag) side effects include headache, fatigue, nausea, and increased liver enzymes. Like Doptelet, it carries a risk of thromboembolic complications due to increased platelets. It may also cause hepatotoxicity requiring liver function monitoring.
It's important to note that liver function and blood pressure monitoring are crucial for managing these treatments. High blood pressure caused by Tavalisse can increase the risk of heart attack and stroke.
If you're pregnant or breastfeeding, Tavalisse is not considered safe for you to take. Your doctor will likely monitor your blood pressure when you first start taking Tavalisse and continue checking it throughout your treatment. If new or worsening high blood pressure develops during treatment, your doctor may prescribe another medication to help manage it.
If medication isn't effective to manage your blood pressure, your doctor may stop prescribing Tavalisse. Your doctor will usually check your blood pressure every 2 weeks until determining the Tavalisse dosage that's right for you, then once per month.
Be sure to talk with your doctor about your health history before you take Tavalisse, as it may not be the right treatment for you if you have certain medical conditions or other factors that affect your health. During treatment with Tavalisse, call your doctor right away if you have symptoms of very high blood pressure.
Symptoms of an allergic reaction can include skin rash, itching, flushing, etc. For mild symptoms of an allergic reaction, call your doctor right away. For serious symptoms, immediately call 911 or your local emergency number. In rare cases, Tavalisse can cause a hypertensive crisis, a type of sudden, severe increase in blood pressure.
For Tavalisse, heavy alcohol consumption can both cause liver problems and affect how well your body processes the medication. If you have questions about drinking alcohol during treatment with Tavalisse, talk with your doctor.
When it comes to managing your health during treatment with Tavalisse, Doptelet, or Promacta, open communication with your doctor is key. Always discuss any concerns or questions you may have to ensure the best possible treatment outcome.
