Ketogenic Supplement Shows Promise in Angelman Syndrome Trial
A dietary supplement, designed to mimic the effects of a ketogenic diet, has shown promise in a small clinical trial involving children with Angelman syndrome. The trial, conducted over 16 weeks, found the supplement to be well-tolerated by the young participants.
The study, divided into four phases, each lasting four weeks, included 14 children aged 4 to 11. It aimed to assess the supplement's tolerability, with 13 children successfully completing the trial. Two minor adverse events were reported, but overall, the supplement was deemed safe.
The supplement, known as ketogenic medical food formulation (KF), contains ketones and was provided by Disruptive Nutrition. Its efficacy could not be determined due to the small sample size, but it was not found to be harmful. Some families reported a reduction in their children's food-seeking behavior while on the supplement.
Almost all participants experienced a softening in stool consistency, which was considered a positive effect by families. A larger and longer trial is now needed to confirm the supplement's safety and determine its efficacy in treating Angelman syndrome.
The trial met its primary goal, demonstrating the supplement's tolerability in children with Angelman syndrome. Half of the families chose to continue using the formula after the study. Further research is required to fully understand the supplement's potential benefits and effects.
