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Ibuprofen and paracetamol led to a girl developing ulcers and a skin rash.

Patient undergoing hospital treatment continues her medical care.

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Ibuprofen and paracetamol led to a girl developing ulcers and a skin rash.

Warning: Graphic Content

A Tumen local, Maria, woke up in the dead of night to a living hell, as horrendous sores and a rash erupted all over her body after taking paracetamol and ibuprofen, as reported by Liter.kz, citing SHOT.

Maria, a 28-year-old resident, was writhing in agony, her head ablaze with unbearable pain and her lips severely swollen. The rash and sores were a terrifying sight, making her unrecognizable.

Her temperature skyrocketed to 39 degrees, and she immediately dialed for an ambulance. As she relayed her ordeal to SHOT, doctors diagnosed her with Stevens-Johnson syndrome - a brutal, multi-causal, allergic disease. She was rushed to the hospital, unable to eat or drink due to the intense pain.

Maria also alleged that doctors detected mycoplasma pneumonia in her. She believed she had it twice before, as her body supposedly had antibodies. She suspected this might have been the trigger for her reaction to the common painkillers.

It appears that her body developed a severe, unpredictable allergic reaction to paracetamol and ibuprofen, two common medications. Stevens-Johnson syndrome (SJS) is a severe adverse reaction associated with both these drugs. While the exact risk of SJS in combination isn't definitively known, given their independent associations with severe skin reactions, the risk might theoretically increase.

Factors that contribute to SJS include idiosyncratic reactions (unpredictable, immune-mediated reactions linked to genetic factors like HLA-B1502 or HLA-A3101 in some populations), high doses or prolonged use of the drugs, and pre-existing vulnerabilities such as a history of drug-induced hypersensitivity or immune-compromised states.

Early symptoms of SJS include fever, rash, and mucosal ulcers. Advent of such symptoms necessitates immediate discontinuation of the suspected trigger and urgent medical care.

While SJS is relatively rare with either drug alone, the combination lacks robust epidemiological data. Individuals with prior hypersensitivity to NSAIDs or paracetamol are advised to exercise caution. Always consult a healthcare professional before self-medicating.

  1. Maria's supposedly previous encounters with mycoplasma pneumonia might have triggered her severe allergic reaction to ibuprofen and paracetamol, as reported by SHOT.
  2. In Maria's case, the old painkillers, ibuprofen, and paracetamol, were the supposed culprits for her development of Stevens-Johnson syndrome (SJS), a cruel, multi-causal, allergic disease.
  3. The health-and-wellness world should be aware that SJS, a severe adverse reaction associated with common medications like ibuprofen and paracetamol, exists and can have devastating consequences.
  4. Mental-health and skin-care advices often overlook the potential risks associated with therapies and treatments, like Stevens-Johnson syndrome, which can be triggered by seemingly harmless painkillers such as ibuprofen and paracetamol.
  5. In the light of Maria's harrowing experience, the science community should consider investigating the risks of the combination of ibuprofen and paracetamol, particularly concerning their associations with severe skin reactions like Stevens-Johnson syndrome.
Patient undergoing treatment in the hospital.
Patient remains hospitalized, undergoing ongoing treatment.

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