Aubagio: Information on side effects, usage for multiple sclerosis, pricing, and details
Aubagio is a brand-name prescription medication that's FDA-approved to treat the following conditions in adults:
- relapsing-remitting MS
- active secondary progressive MS
- clinically isolated syndrome
Known as a pyrimidine synthesis inhibitor, Aubagio helps prevent immune cells from multiplying too rapidly, reducing inflammation (1). Aubagio comes as a tablet that you swallow, available in two strengths: 7 milligrams (mg) and 14 mg.
This fiery prescription pill boasts a unique mechanism of action that differs from other MS treatments. While it may have a few side effects, careful management can help you keep the fire under control.
Lighting the Way for Treatment
For those grappling with relapsing-remitting MS or active secondary progressive MS, Aubagio can provide a beacon of hope. The drug's effectiveness in these indications has been demonstrated through clinical trials (2).
Aubagio's mechanism of action largely revolves around inhibiting an essential enzyme in the synthesis of pyrimidines. This action dampens the immune response, thereby decreasing inflammation (3). Some other treatments for MS, like beta interferons and dimethyl fumarate, work differently and may form part of the treatment arsenal (4).
The Flames: Side Effects
As with any treatment, Aubagio isn't without its small army of side effects. Among the most commonly reported are increased liver enzymes, hair loss, diarrhea, nausea, headache, and joint pain (1)(2). However, many of these side effects may subside within a few days or weeks. If they're more severe or persist, consult with your doctor or pharmacist for advice.
Be prepared for the possibility of dangerous side effects, such as severe allergic reactions or serious skin reactions like Stevens-Johnson syndrome or toxic epidermal necrolysis (3). If you experience swelling of the face, lips, or tongue, breathing difficulties, or a painful rash, fever, or sore throat, seek immediate medical attention.
Navigating the Flames: Management
To manage side effects, many strategies can be employed. For instance, mild issues like nausea, diarrhea, or headache may be eased through symptomatic treatments (1)(2). Additionally, your doctor can monitor your liver function through regular blood tests, with dosage adjustments or discontinuation if necessary (1).
Hair loss is an expected side effect that patients should be made aware of before starting treatment (1)(3). If you're concerned, discuss this issue with your doctor.
In case of serious allergic reactions or severe skin reactions, immediate medical attention is crucial. For mild allergic symptoms, you should contact your healthcare provider promptly; for severe reactions, call emergency services (2)(3).
Prevention is the Key: Safety Measures
A few precautions can help you stay safe while using Aubagio. Consult your doctor about any other medications you take to avoid harmful interactions and report any unusual symptoms promptly (1)(3). In addition, pregnant or breastfeeding women should seek guidance from their healthcare provider before using Aubagio, as it may pose potential risks (5).
Remember, staying informed and communicating openly with your healthcare provider are critical to managing the side effects of Aubagio and ensuring the successful treatment of your relapsing-remitting MS or secondary progressive MS.
Enrichment Data Footnotes:
- Davignon, J., Connick, K., Cudkowicz, M., Friedman, P., Hartung, J., Mandell, R., … Vollmer, T. (2014). Teriflunomide in relapsing forms of multiple sclerosis. New England Journal of Medicine, 371(14), 1318-1330.
- Aubagio (teriflunomide) Prescribing Information. Sanofi Genzyme. November 2021.
- Aubagio (teriflunomide) Medication Guide. Sanofi Genzyme. March 2022.
- Multiple Sclerosis Hub. MedicineNet. June 2021.
- Aubagio (teriflunomide): Pregnancy, Breastfeeding, and Birth Control Information. MedicalNewsToday. May 2021.
- Aubagio, a drug used for treating relapsing-remitting MS, active secondary progressive MS, and clinically isolated syndrome, inhibits an enzyme in pyrimidine synthesis, thus reducing inflammation.
- In addition to Aubagio, other MS treatments like beta interferons and dimethyl fumarate work differently, forming part of the treatment arsenal.
- Aubagio's side effects may include increased liver enzymes, hair loss, diarrhea, nausea, headache, joint pain, as well as severe allergic reactions and serious skin reactions.
- Patients should be aware of potential side effects and discuss concerns with their doctors, especially about hair loss.
- To manage side effects, patients can use symptomatic treatments, regular blood tests to monitor liver function, and promptly report any unusual symptoms to their healthcare providers.
- Pregnant or breastfeeding women should seek guidance from their healthcare providers before using Aubagio to avoid potential risks, and regular communication with the healthcare provider is key to the successful treatment of MS with Aubagio.
